macrophage – large. eating. cell.

Laying out and studying a white blood cell called a macrophage (Greek makrós – large, phagein – to eat).

macrophage

Big eater, what’s your specialty?

Macrophage, your lot belongs to the immune system. You are King of the Phagocytes. Phagocytes are cells that protect the body by absorbing/eliminating harmful particles, bacteria and dead or dying cells. M1 macrophages attack invaders (microbes) by creating an area of inflammation around them. Perhaps you keep pathogens from spreading? M2 macrophages decrease inflammation and encourage tissue repair.

Side note…
Based on this, can I make 2 simple assumptions? Can I deduce chronic inflammation signifies organ or tissue has been invaded by a pathogen or there is injury?

Macrophage, you can take up residence in specific organs. For example, they call you Microglia in the CNS,  you are a Kupffer cell in the liver, and Adipose tissue macrophage in Adipose tissue. And other macrophages, like scavengers, you wander the body cleaning it up.

You remove dying or dead cells and cellular debris by engulfing pathogens and digest/destroying them. Sometimes a pathogen sabotages your process and decides to live inside of you. In the case of the latter, the immune system doesn’t have a clue (or does it?) as the invader begins to replicate itself.

macrophage with bacteria and debris

I know you a little better because I’ve drawn you. You are as intimidating as you are beautiful.


Postscript:
Right now I am looking at the relationship between gut bacteria ( the microbiome) and adipose tissue. Here now enters the immune system. The reason I took the time to draw out and investigate the macrophage (I don’t pretend to understand.) is because I made a connection to the microglia in the brain.
I was studying the brain (My father lives with Alzheimer’s Disease.) last summer. I keep thinking and saying I will go back to the brain when I finish whatever I am currently working on…but as it is…it really is all connected.
#SmallPictureIsBigPicture #Connections #Art #Life #Science


©2019 ALL RIGHTS RESERVED BY MONICA AISSA MARTINEZ

art on a cellular level

What:    Art on a Cellular Level
Where:  Phoenix Sky Harbor International Airport
Terminal 4, Level 3 Gallery
When:   Now!
Opened June 29, 2019 and runs through January 12, 2020

Portrait of Pillar

Arizona artists include:
Alan Bur Johnson, Jerome AZ
Bill Dambrova, Phoenix, AZ
Danielle Wood, Tempe, AZ
Jesse Armstrong, Gilbert, AZ
Kathryn Maxwell, Tempe, AZ
Mary Meyer, Gold Canyon, AZ
Monica Aissa Martinez, Phoenix, AZ

Science and art have a lot in common. Driven by curiosity, both fields involve exploration and discovery. Relying on observation, scientists and artists both attempt to understand and describe the world around us. They strive to see things in new ways and to communicate that vision.
While science may embody the rational, art expresses the aesthetic. This exhibition presents the work of seven artists that draw inspiration from the natural environment. With an interest in living organisms, these artists create works that celebrate the richness of life on our planet.

Artists, like scientists, utilize processes to make the unseen visible. They imaginatively represent things that we would need a microscope to see. From molecular structures of DNA to patterns of organic forms to the intricacies of human anatomy, these artists draw, paint, sculpt or construct Art on a Cellular Level.

Couple in front of the work of Bill Dambrova.

Over the 4th of July holiday while traveling, I enjoy watching people move through the space. ↑

I meet an emergency medic and his wife, who talk to me about the vegus nerve and the breath. ↓

The Phoenix Airport Museum is one of the largest airport art programs in the United States.
More → Sky Harbor Museum

drawing – a system of connecting parts

The six-sided, very cool and highly complex structure below ↓ is a section of the hepatic lobule (at the microscopic level). It represents a building block of the liver that includes (at all the edges) blood and bile collecting vessels called portal triads: a portal artery (red), portal vein (blue) and bile duct (green).

liver lobule

I isolate and detail a lobule of the liver into the Portrait of Carolyn because I want to know where Kupffer cells hang out. They’re the smallest and brightest orange (in my ↑ study) circular forms in the sinusoids (blue central lines). Kupffer cells work to remove debris (bacteria and their product) and worn out blood cells from blood before returning it back to the heart.

And speaking of bacteria, this portrait study is the first to include microbes (archaea, bacteria, fungi, protists and viruses).

The study of these invisible-to-the-eye life forms include a language I might never grasp. Take the word Firmicutes (firmus, strong and cutis, skin), a playful word that basically means a division or category of bacteria.  Firmacutes, like the Streptococcus below, are labeled gram-positive. This sounds like a good thing, doesn’t it? (I have an urge here to remind you that I am an artist not a scientist.)

If I had to rate the status of the relationship between human and microbes, I say…It’s complicated!

I continue to learn about microbes and the human microbiome. I’ve become curious about cancer causing pathogens. I look for more info on viruses in particular.

While Carolyn’s diagnosis of breast cancer is the impetus for the drawing, it’s not necessarily the focal point. A whole biological system/environment is the focus of the study.

Between the fig and the fibula – that’s where you’ll find #Feisty the cat. #portraitofcarolyn #ecosystems

Drawing a #drawing. Painting a #painting. #PortraitOfCarolyn #ShesAnArtist  #WorkInProgress

I brought in #WildBlueberries (Lots of them cuz they are Queen of the anti-oxidant foods #flavonoids.) and #bananas (favorite source of #potassium). #foodasmedicine

Added a #green #herb to the drawing yesterday. Ate it while I drew it! 💚#Cilantro. Loaded w vitamins and minerals. 💚💚 #phytonutrients #flavinoids #cineole #linoleic #dodecenal

Good time to mention the composition also includes intestinal epithelium cells ↓ that form the lining of the small and large intestines. The lining absorbs beneficial matter into the body as well as restricting harmful substances.

Over Spring Break, Carolyn and I drive to San Diego to pick up her artwork from an exhibition. Would I like to visit a tourist site? She asks while describing a stone house with a tower. Off of Interstate 8 we pull into Desert View Tower.

It feels good to move around, we hike an area of rocks and eventually make our way to the building. We climb a spiral staircase leading to a tower where we experience the view of wide open landscape. There’s a bronze bell up there too, which I photograph for no particular reason, except that I like bronze bells ( I own 2 of them).

Back in the studio I recall a conversation:
I’ve meant to tell you something. I think you’ll like this! Carolyn says. She tells me about a brass bell she’d rang at the cancer center that marked the end of her radiation treatment (and maybe the beginning of something new). It’s a tradition that all patients celebrate, she explains. I’d never heard of it. Was Brian with you? She nods and says Yes!

#wip
The work continues…connecting the parts.


© All Rights Reserved by Monica Aissa Martinez

organ of vision

My friend Wright gave me some books early this week. One of them is titled Medical Meanings, A glossary of Word Origins. I look up ‘eye’ and this post is born.

Eye comes through the Old English ēage from the Teutonic auge, all of which refer to the organ of vision. Incidentally, the Old Norse vindauga, “wind-eye” became our “window.”

The paragraph finishes with:
In years past, the upper canine tooth was called the “eyetooth” in the mistaken belief that it was connected to a branch of the same nerve that supplies the eyes.


Carolyn brings over a couple of different sets of medical images. One includes profile shots of her head. The cover reads Full TMJ Right Closed & Left View. I pop it into my laptop, pull up the images and recognize Carolyn’s facial bone structure.

I already know a direct image will be the focus, right then I am certain a profile drawing will also be incorporated into the composition.

Life-size studies are a lot about research and getting general anatomy organized. When it comes to details like the facial features, I very much enjoy the act of drawing ( mostly graphite, some color pencil and an eraser kind of drawing). I like capturing likeness. The challenge eventually is to bring anatomical detail in and not lose resemblance.

Obviously I focus on the eyes (eyeballs) with Carolyn.

Initially I outline her profile into the upper right-hand corner of the picture plane and leave it there for some time.

Taking a second look at her x-rays yesterday, I change my mind and decide I prefer it to the left (her right).

Before I realize it, I am incorporating the brain….not in the plan but it makes sense why I do it and it may stay.


PS…
At the end of the day – the drawing tool appears in hand. 

#Eye #Hand #Brain
#Artist #OrganOfVision #WIP

micro to macro

“The task of the right eye is to peer into the telescope,
while the left eye peers into the microscope.” 

I understand this quote from artist (Sorceress of Mexico) Leonora Carrington more after a periodic table of elements makes its way into my drawing last week.


January 6, 2019
What are you eating these days Carolyn?

Raw honey is big. Radishes, apples, especially pink ladies, and I juice an orange nearly every day. Now we are in grapefruit season so I am adding that.  I also eat a lot of tomatoes, cucumber, zucchini and cabbage. And I eat a bit of radicchio everyday. Love it. And every day is guacamole. Potatoes are nearly every day. Sprouts are every day. Sage is nearly every day. Seaweed mostly Dulse everyday. And lots of asparagus and Brussel sprouts. Lots of grapes, raspberries, mushrooms and bell peppers. Greens every day. Haha, enough?

She doesn’t mention celery juice. Nor does she say anything about the cilantro she hands me as a snack almost every time I visit lately.

Carolyn is not necessarily raw Vegan, though she’s post radiation treatment and is still in cleanse mode.

Grounding the composition in fruits and vegetables, I gather bits of nutritional value for a few of them, to share on social media. They are like small vignettes with running text – easy and informative.
#FoodAsMedicine #MyQuickNotes #Education #InCaseYou’reCurious

#DrawingCelery. ❤️#JuicingCelery.#FoodAsMedicine Vitamin K, folate, potassium, fiber, manganese, pantothenic acid, B12, B6, calcium phosphorus, magnesium, flavonoids, carotenoids (VitA), non-starchy polysaccharides (pectin), apiuman (#anti-inflammatory!),  #antioxidant! #phytonutrient!

🐝 #pollen as #medicine. #Raw 🍯 is honey as it exists in the hive (contains pollen). 22 amino acids, 31 minerals and plenty of vitamins and enzymes. Micronutrients acting as antioxidants reduce inflammation, lower risk of ❤️ disease and some cancers. #BeesRock. #Raw ❤️🐝🍯

🍎medicine: Increases acetylcholine (an essential neurotransmitter 👈🏼), strong 💪🏻 antioxidant, she holds B-Complex maintaining ur blood cells and again ur nervous system, she offers good ole VitC, and plenty phytonutrients (protection from free radicals), some fiber, calcium, potassium, and phosphorus. Call her 🍎miracle fruit. 1 a day (or 2) x years = nutritional powerhouse. Avoid the seeds. These are #PinkLadyApples #justeatit

Tomato. 🍅 Or is it tomatl (Nahuatl)? This berry may have originated in Mexico. The Spanish encountered the 🍅 from their contact w the Aztec. #Mesoamerican #antioxidant #lycopene #vitaminC #potassium #folate #vitaminK Sketching tomatls in the am.

🥒 Cucumber medicine: Benefits skin, eye health, balances body’s PH level, eliminates bad-odor causing bacteria (bad breath), good for ur ligaments, cartilage, tendons, bones, hair, supports neurological function, has anti-cancer properties, supports normal flora and peel is beneficial too. I could go on. Who knew the list was this long! And it’s a fruit. Slice it, juice it. #Hydration #FoodAsMedicine Draw it 🥒 Paint it 🥒

#dandelion #greens #medicine #bitterherb Interesting thing about this ‘weed’ – every part of her is considered medicinal including root. This one came from my neighbors yard. #anti inflammatory #anti carcinogenic #anti-oxidative Easier to eat than to draw.

Drawing #radish today. #FoodAsMedicine. Holding #sulfur #vitC #fiber = anti-fungal, anti-cancer and digestion aid. Interesting thing about the radish – its companion plant is the cucumber. They thrive best growing near each other. #Ayurveda #TCM

I not only consider the elements found in the body but also the make-up of the food that sustains it. Enter: The periodic table of elements.

Red squares represent elements that compose our human body while fewer warm tones represent trace elements. I include symbol and atomic number.

I add in a few microorganisms, bacteria ↓ in this case.

And maybe archaea (pointing to time past) ↓.

And here are things 22 days later…


On a morning run, I listen to a lecture on the periodic table. The information really  does take my attention from microscope to telescope. Minutes later I come across side-walk chalk-art.
#Cosmic #BigBang #WeAreOne

i draw beautiful whipworms (note to self – these are parasites)

What a nice surprise to hear from María Adelaida. I’m pleased to learn she keeps an eye on my work as she notes my recent activity on microorganisms.

I know María from years back (2008-09). She is a biologist originally from Colombia, she’s in the valley working for the Mayo Clinic when I meet her at a friends party. She attends one of my art openings before moving to Germany to continue her education.

These days she lives in the UK and works at the Sanger Institute. Her current research is intestinal parasitic worms that cause neglected tropical diseases with a huge impact on children.

She has an idea for collaboration that includes a public engagement project.  Does she know how often I think about opportunity to engage with the public? It’s on my mind a lot especially after my summer artist residency at the Tempe Center for the Arts.

Maria Adelaida’s research is the Whipworm and Trichuriasis.

We talk about art as a form of communication. She talks about her work reaching a new audience. I enjoy the idea of my work reaching a different audience as well. She speaks STEM, I bring the A in and speak STEAM.

I’m intrigued. Can you send photos of these whipworms?

She sends a series of electron microscope images. Oooooh! The first ones, in black and white, defined and beautiful, show the marking and pattern of the male worm. He appears to float in stillness (I don’t imagine the intestines are a quiet place. Are they?)

Soon I receive a Powerpoint of larvae that is out of the eggs, she says, in the presence of bacteria. (I can’t identify the bacteria.) And then more photos patterned and stained bright show the internal structure of an adult female whipworm infecting the cecum of a mouse. A transversal section shows the eggs.

I make time to get to my drawing table. I want to better understand what I see.

Cecum, Eggs and my imagination.

I spend a day drawing the cecum, a pouch connecting the small and large intestine. I imagine the area with little light (dark) so I take my drawing into a filter and play with it ↑.

Cecum is from the Latin caecus and means blind – blind intestine, blind gut or cul de sac.
Maria identifies the super beautiful cecum epithelia and explains it is only a single layer of cells, that is folded in ‘crypts’ to maximize the area. 

I note the eggs. I wonder how long they take to hatch. (Is this the correct language? Do they hatch?)

I spend a few days looking at photos and drawing worms. Yes, they do resemble a whip.

The female is larger than the male. I’m surprised to know the thinner narrower end of the worm is where the mouth is located while the wider end is its rear.

I take the image into a filter and again imagine the inside of the large intestine.

I get lost in the drawing.  I have to remind myself these are parasites that cause serious problems to the host. #DrawingInProcess #2sided


I learn from Dr María A Duque-Correa whipworm infection causes Trichuriasis, which affects millions of children around the world. Her goal is to more fully understand the initial stages of the epithelia infection by the larvae, a crucial step that determines whether the worms are expelled or remain in the gut causing chronic disease. In the long term, this knowledge will help to develop vaccines and discover drugs to fight whipworm infections.

Here is one of her public engagement programs → Worm Hunters.

Crossing my fingers that we will work together in the future.

portrait of carolyn – body female

It’s late July when after taking care of the various recommended health screenings, my friend Carolyn has a biopsy. She calls to tell me she’s diagnosed with stage zero breast cancer.

Stage zero! Stage zero? What does this mean? In the course of our conversation I feel myself in repeat mode…Stage zero! Stage zero? 

Diagnosed with ductal carcinoma in situ (DCIS), she explains the cancer cells are contained. They’ve not spread outside of the ducts or lobules into surrounding breast tissue.

Carolyn, a visual artist, problem solves. Research, discipline and commitment are all part of the creative process in the studio. She now directs these well-honed skills towards creating balance in her health and wellness. She chooses to clean up her system. For Carolyn, this means going vegan.

She surrounds herself with an integrative medical team including her regular primary care physician who is a D.O. (internal medicine), a medical oncologist, a cancer surgeon, a plastic surgeon, a radiation oncologist, a naturopathic physician, a physical therapist, a lymphedema specialist and she brings in a licensed acupuncturist.

August 23 she undergoes a 5 1/2 hour surgery for stage zero breast cancer followed by  a traditional course of radiation which she completes November 6th. Carolyn opts out of the 5 year hormone (suppressing) therapy that often follows radiation. 

I photograph and outline her body the following Saturday afternoon. I return to my studio and Carolyn heads to the Grand Avenue Street Festival.

Carolyn is open about her medical history and consequently I know a fair amount…of interesting things. Her medical records are impressive. They are carefully organized with an object-like quality almost like the cut-outs she collects to work her drawings. Still, I never expected to draw her.

Back in the studio, it’s been a while since I work out a full-scale human. In the interim I’ve learned much more about body organs and systems. And I crack the door and peek into microorganisms and the human microbiome. I am curious to see how the latter will enter the picture plane.

As I work, I recall a few years back, a conversation with Carolyn about the ileum (highlighted below ↓ in orange). It’s a space in the small intestine where the body stores Vitamin B12. I’m fascinated that such an area exists. #thebodyamazing

Carolyn takes B12 regularly these days.

In the small intestines you’ll find the ileum. To the left is the cecum (the start of the large intestine) and below it is the appendix. Lower right corner is the edge of the rectum.

I lay out the structure as I consider the narrative of this new work. It is a very good time to talk about women’s health and wellness.

Work in Progress Portrait of Carolyn (on Arches Hot Press) 7×4′

A body human: portrait of the private and the public, the social and the biological.


Carolyn is an artist who lives in Phoenix, AZ. I know she’ll appreciate me telling you she grew up in Washington, outside of Seattle. She is married to a good guy. Brian surprised (and impressed) me when he handed me an article about the benefits of cilantro.
Oh…and cats! they live with lots of cats (maybe 4).